Center for the Prevention and Treatment of Visual Loss
Oliver W. Gramlich, Ph.D.
Investigator, Center for the Prevention and Treatment of Visual Loss
Phone: (319) 335-7537
MS, Zoology, Gutenberg University
PhD, Neurobiology, Gutenberg University
Post Doctural, Ophthalmology, Gutenberg University
The degeneration of the optic nerve is a major hallmark of optic neuropathies and demyelinating disorders such as glaucoma or multiple sclerosis (MS). Two cells are vital to the transport of visual information through the optic nerve from the retina to the brain: retinal ganglion cells and oligodendrocytes. Retinal ganglion cells are the neurons which form the axons of the optic nerve, and oligodendrocytes wrap those axons with their insulating, cholesterol-rich myelin sheath. Chronic stress to either or both cell types ultimately leads to the death of retinal ganglion cells causing permanent vision loss and blindness.
My research aims are to determine the pathobiology of initial neuroinflammatory processes leading to retina ganglion cell and oligodendrocyte degeneration using human donor tissue, animal models, and in vitro systems. I am focused on discovering new stem-cell and drug-based approaches for rehabilitation of vision loss with rapid translation of new findings into clinical practice.
My current projects are tailored to investigate how activation of the complement system and immune cells impair GABAergic and glutamatergic signaling pathways and accelerate retinal ganglion cell death in glaucoma. The goal is to inhibit the incipient inflammation and to supplement the high energy demands of retinal ganglion cells to restore their function and prevent cell death. The rehabilitation of retinal ganglion cells leads to improvement of visual acuity and will finally lessen visual field deficits.
In MS, one key opportunity for rehabilitation is the repair of the myelin sheath after an immune cell attack. I work on augmentation to increase cholesterol recycling and fatty acid metabolism providing the highly demanded energy to maintain signal transduction through the optic nerve and material for re-assembling the damaged myelin sheath. The strengthening of signal transduction in denuded axons significantly increases the likelihood of oligodendrocyte precursor cell differentiation and remyelination of those axons. Encouraging remyelination in MS improves conduction speed and will determine the magnitude of rehabilitation.
- Early Functional Impairment in Experimental Glaucoma Is Accompanied by Disruption of the GABAergic System and Inceptive Neuroinflammation. Gramlich OW, Godwin CR, Wadkins D, Elwood BW, Kuehn MH. Int J Mol Sci. 2021 Jul 15;22(14):7581. doi: 10.3390/ijms22147581. PMID: 34299211
- Targeting Cholesterol Homeostasis Improves Recovery in Experimental Optic Neuritis. Godwin CR, Anders JJ, Cheng L, Elwood BW, Kardon RH, Gramlich OW. Biomolecules. 2022 Oct 7;12(10):1437. doi: 10.3390/biom12101437. PMID: 36291646
- Acriflavine, a HIF-1 inhibitor, preserves vision in an experimental autoimmune encephalomyelitis model of optic neuritis. Anders JJ, Elwood BW, Kardon RH, Gramlich OW. Front Immunol. 2023 Oct 23;14:127118. doi:10.3389/fimmu. 2023.127118. PMID: 37942317